Genes Responsible For Sleepy Feelings

Genes responsible for the 24 o'clock hour body affect not only the timing of sleep, but also appear to be of crucial importance for the proper remedial measures process of sleep, according to research in the online Open Access journal BMC Neuroscience . The study identifies changes in the brain, leading to a greater desire and need to sleep during the time awake.

"We still do not know why we benefit from their sleep, or why we believe that when we are tired" missing "sleep, but it seems likely that sleep serves some basic biological function of the brain, such as energy for the restoration of brain cells and memory consolidation. , "explains Dr. Bruce O'Hara of the University of Kentucky, a neuroscientist who led the research. "We have noticed that clock gene in the brain is highly correlated with the development of the sleep debt, while the earlier results, these genes to energy metabolism. Together, this supports the idea that a function of sleep is associated with energy metabolism. "

To the connection between the expression of clock genes and sleeping, 03 inbred strains of mice with different genetic tests were used, and the previously demonstrated differ in their response to sleep deprivation from lead author, Dr. Paul Franken of Stanford University and the University of Lausanne. In this study, mice were first deprived of sleep during the day time mice normally sleep then recovery sleep. Changes in gene expression for genes were three in the whole brain during the two phases. Clock gene generally increased the more the mice were kept awake and went to sleep if allowed, the support that these genes play a role in regulating the need for sleep. Generally, the expression of genes-hour period - Period 1 and 2, increased at a faster mouse strains with the poorest quality of recovery sleep that the detailed dynamic changes in the expression May underlying individual differences in sleep duration and quality of sleep. The changes in gene expression were also shown that in many different brain regions support the idea that sleep is a global brain.

A handful of genes as period - Period 1 and 2 were previously based on our circadian rhythms (behavior and physiology, a 24-hour cycle). The big advantage of circadian rhythms is that the animals and plants to forecast and prepare for the regelm�ige changes in the environment. The anticipatory rise of the clock-gene may be, at the molecular level, an animal in the preparation for the activity. Variations in May clock genes underlying rhythmic characteristics affect our preferred wake-up time, but the clock genes' role in the direct regulation of sleep, as in this study, may also influence sleep duration and human performance with different amounts of sleep . The research could also help shed light on the biology of mood disorders, such as Seasonal Affective Disorder (SAD) or bipolar disorder, which appear in connection with both sleep and circadian rhythms.

----------------------------< Br> Article adapted from Medical News Today from the original press release. ,

article : A non

role for the circadian clock genes in sleep homeostasis: a burden compared

Paul Franken, Ryan Thomason, H. Craig Heller and Bruce O'Hara F

, BMC Neuroscience , (in press)

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Source: Charlotte Webber

BioMed Central