Soundly Sleep can make stay young

Are you desperate for insomnia that do not heal? Among the many biological functions, which is regulated by the body clock cycle is a metabolic regulator. This is a metabolism that makes the body rushed in the morning and slows down every night. Now, researchers have identified genes that awaken people from sleep every day. This is an initiative to raise metabolism genes in the morning. Like a car, this gene works as a "starter" who started the day your metabolism every morning arrives. This important discovery could provide clues to solve problems, such as insomnia, aging, even cancer, and diabetes. Jef Akst wrote the findings in the science magazine The Scientist a while ago.

Soundly Sleep can make stay young
Body cycle is commonly called circadian cycle that lasts 24 hours of endogenous hormones in the body is driven biochemical, physiological processes, and behavior. Circadian rhythms have been widely studied in plants, animals, fungi and cyanobacteria. Circadian that determine the body's daily biological rhythm, biological tides, "rhythm" of the body weekly, seasonal, and annual.

"The body is essentially a collection of hours," says Satchidananda Panda, coordinator of the research team study the biology of the Salk Institute San Diego, United States. "We know the mechanisms that instruct the body clock to slow down at night, but we do not know what makes the body active again in the morning."

"Now we've found it. We can explore deeper to find out how our biological clock is damaged with age and the development of chronic diseases."

The researchers found that the protein "JARID1a" serves as a press button to turn on circadian circuit by forming a complex of genes: the gene CLOCK and BMAL1. This complex of genes which then affects the production of PER - protein expression following 24-hour cycle performance.

The researchers found that production of the PER protein in the human body was low in the morning. Production of low PER is what triggers the start operation of the circadian circuitry. For the body, this sort of alarm to begin to move in the morning.

By examining the human body cells, mice and fruit flies, the researchers found in detail the role JARID1a protein in normal cells and in an active state, such as cycling. It was found that cells that have abnormally low expression JARID1a turned out to make the production of PER proteins fail to reach the top.

PER production that does not reach the peak or low it is an indicator that the circadian circuit is in normal circumstances. In the normal circadian circuit condition, the human body is ready to start their daily activities.

In this research also found that the fruit fly, animals that have low levels of PER often "forget time". This explains why the flies often slept all day and night.

This finding is the beginning of an effort to find out JARID1a role in sleep disorders or chronic illnesses. Next target, find new drugs to overcome the interruption.

"A good night's sleep is very useful for our health and make us stay young," said Panda about this discovery. "Now we are able to identify the role JARID1a to enable our daytime cycle. We have a new way to explore the breakdown of circadian rhythm in some people (which makes sleep disorder) and find new ways to help them."